HARISSA is the acronym of ESO/VLT/SPHERE large program of high angular-resolution imaging survey of asteroids. The program was granted by 152hours of observations for five semesters, between 2017 and 2019. Its objective was the survey of a representative sample of large asteroids (diameter larger than 100km) for ~35 objects throughout their rotation. The presentation will point some results of highlighted science produced and published of this program.