The ESAC Science Data Centre (ESDC) hosts the scientific  archives from the astronomy, planetary, heliophysics, and human and  robotic exploration missions from ESA. In particular, at the ESDC we host mirrors of the Hubble Space Telescope and the James Webb Space Telescope archives, as well as the main archives for many other astronomy missions such as Planck, Herschel, XMM-Newton and Euclid. These archives represent more than three decades of space‑based astronomy and their science archives offer tremendous potential for new discoveries. In addition to the archives, at the ESDC we have developed ESASky (sky.esa.int), a web application to discover astronomical data from ESA and other partner agencies and ground based observatories, and ESA Datalabs, a science platform that allow users to discover, access and analyze the data from these missions  on premises, without the need to download anything. In this presentation I will show how users of the eHST, eJWST and Euclid Data Space can take advantage of ESASky and ESA Datalabs science platform to implement and execute end‑to‑end research workflows. This is possible thanks to two very intuitive user interfaces that combine search tools to discover the  data from HST, JWST and Euclid,  analysis and calibration software for the case of JWST, and the necessary computational resources, all in the same data centre.