I present the first results of a long term project devoted to the study of the evolution of the binary population in globular clusters. Using deep ACS@HST images of a sample of 13 globular clusters I estimated the fraction of binaries in the cores of these clusters. From a theoretical side, I developed a simplified analytical code which simulates the evolution of the properties of the binary population in a dynamically evolving globular cluster. The comparison between theory and observations allows to evaluate the efficiency of the various processes of binary formation and destruction in these stellar systems and their dependence on the main cluster structural and dynamical parameters.